STUDIES ON ANTIGENICITY
نویسندگان
چکیده
منابع مشابه
Studies on Antigenicity
The enzymatic degradation of fluorescein conjugates of poly-L-lysine, poly-D-lysine, and exhaustively succinylated poly-L-lysine by aqueous extracts of spleens from "responder" (guinea pigs which can develop immune responses to hapten-poly-L-lysine conjugates) and "non-responder" guinea pigs was investigated. The in vivo degradation of H(3)-tagged dinitrophenyl conjugates of these synthetic pol...
متن کاملPerspectives on antigenicity and idiotypy.
The recent crystal determination of a lysozyme-antilysozyme complex provides a three-dimensional prototype of the manner in which contacts in idiotype-anti-idiotype interactions may be realized. Such interactions can be approximated by two complementary "flat" surfaces. Each IDR (autoantigenic locus) location might provide a particular recognition feature between two interacting partners. The c...
متن کاملGonococcal pilus vaccine. Studies of antigenicity and inhibition of attachment.
A gonococcal pilus vaccine or placebo was injected subcutaneously or intramuscularly into 71 human volunteers. The vaccine was found to be safe. The principal adverse reaction was a complaint of a sore arm, which was caused, at least in part, to the volume of material injected. 6 of 64 (9%) volunteers receiving the larger doses also complained of malaise. The vaccine was found to be antigenic. ...
متن کاملStudies on the chemical basis of the antigenicity of proteins. 2. Antigenic specificity of polytyrosyl gelatins.
In the preceding paper it was shown that the attachment of tyrosine, tryptophan or phenylalanine peptides to gelatin converts it into a relatively powerful antigen. The serological specificity of these gelatin derivatives varied according to the nature and the length of the peptides attached. Thus the specificity of polytyrosyl gelatin (10% of tyrosine residues) and polytryptophyl gelatin (25% ...
متن کاملStudies on the Antigenicity of Β- and Α1-lipoproteins of Human Serum
The techniques of agar immunoelectrophoresis and agar double diffusion were applied to the study of the antigenicity of beta- and alpha(1)-lipoproteins separated by ultracentrifugation from normal human sera. The effects of delipidation were also investigated. It was shown that beta- and alpha(1)-lipoproteins are antigenically distinct. For each class of lipoprotein studied, a single antigenic ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1964
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.120.5.955